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- ***************************************************
- * Bacterial-type phytoene dehydrogenase signature *
- ***************************************************
-
- Phytoene dehydrogenase (phytoene desaturase) is an enzyme of carotenoid
- biosynthesis that converts phytoene into zeta-carotene via the symmetrical
- introduction of two double bonds at the C-11 and C-11' positions of phytoene.
- The sequence of phytoene dehydrogenase from bacteria (gene crtI or carC) and
- fungi (gene AL-1) are not related to that from cyanobacteria and plants but is
- evolutionary related [1] to that of another enzyme of carotenoid biosynthesis,
- methoxyneurosporene dehydrogenase (gene crtD).
-
- There are two glycine-rich conserved regions, both of which probably play a
- role in the binding of either FAD or NAD. The first conserved region is in the
- N-terminal section while the second one is in the C-terminal section. We have
- used the second region as a signature pattern.
-
- -Consensus pattern: [FYW]-[LIVMF]-x-G-[AG]-[GS]-[STA]-H-P-G-[STA]-G-[LIVM]
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
- -Last update: June 1994 / First entry.
-
- [ 1] Bartley G.E., Schmidhauser T.J., Yanofsky C., Scolnik P.A.
- J. Biol. Chem. 265:16020-16024(1990).
-